Love triangles, drama and suspense is on the medical chart for "Doc" S2

Reel Perspectives

September 24, 2025

The sophomore season of Fox's medical drama "Doc" returned with a bang on September 23, following Season 1's juicy cliffhanger, in which Amy was caught locking lips with her ex-husband by her current boyfriend. The series is based on the Italian series Doc – Nelle tue mani, and inspired by the remarkable true story of Dr. Pierdante Piccioni, who lost the previous 12 years of his life following a car accident in 2013.

The series follows Amy Larsen, the chief of internal medicine at the fictional Westside Hospital in Minneapolis, who suffered a traumatic brain injury in a car accident that caused her to lose her memory from the past eight years and struggles to rebuild her medical career and personal life.

Co-produced by Sony Pictures Television and FOX Entertainment, the official synopsis for the emotionally charged Season 2 reveals that Amy, no longer Chief of Internal Medicine at Westside Hospital, must restart her medical journey as an Intern in the hopes of becoming the doctor she once was. She'll confront hard truths about her missing years, work to repair fractured relationships, and seek to reconcile the person she used to be with the one everyone else has come to know.

Emmy Award winner and Academy Award nominee Felicity Huffman joins the drama this season in the series regular role of Dr. Joan Ridley, Amy's med school professor and early mentor – and now the new Chief of Internal Medicine at Westside Hospital. Her arrival will surely cause a stir and create even more drama in Amy's life, both professionally and personally.

Ahead of the Season 2 premiere, Hank Steinberg, who serve as co-showrunner and executive producer with Barbie Kligman, teased in an interview with US Weekly, "She's in a rush to get her memories back because she wants to remember who she was as a doctor and get back all that medical knowledge so she doesn't have to be an intern anymore," Steinberg explained. "She wants to remember her love with Jake so that she can get back in with that. She wants to remember the last year she had with her son because she doesn't remember that. So she's got a lot of urgency."

In addition to Molly Parker starring as Amy, the ensemble cast includes Omar Metwally, Amirah Vann, Jon Ecker, Anya Banerjee, Patrick Walker and Charlotte Fountain-Jardim. 

Season 2 consists of a full 22 episodes and promises plenty of emotional drama and suspense. As Amy gets closer to regaining her memory, the season will explore the emotional layers of her journey while also dealing with all the explosive medical drama that unfolds in each episode.

---

New episodes of "Doc" drop every Tuesday at 10 p.m. ET on FOX. Episodes are available to stream the next day on Hulu.

---