"The Second Best Hospital in the Galaxy" returns for another zany season
- The Real Perspectives
- May 28
- 2 min read
Updated: Jul 1
Reel Perspectives
May 27, 2025
The space doctors are back! The raucous adult animation comedy, The Second Best Hospital in the Galaxy, returned for its second season exclusively on Prime Video on March 28, featuring all of its 8 episodes bringing the adult charm, wit, and laughs from the first season.
Set in the Ergulon Galaxy in the year 14002, the series is created by Cirocco Dunlap and executive produced by Maya Rudolph and Natasha Lyonne and follows two daring female surgeons and inseparable best friends, Dr. Sleech and Dr. Klak, who frequently risk everything to take on the most dangerous cases in the universe. Per the official logline, Season Two of The Second Best Hospital in the Galaxy, doctors Sleech and Klak relish the fame of their recent success until a cyborg journalist starts digging a little too deep into Sleech's past.
The series stars Stephanie Hsu (Everything Everywhere All at Once), Keke Palmer (One of Them Days), Kieran Culkin (A Real Pain), Sam Smith (Spectre), Maya Rudolph (Loot), and Natasha Lyonne (Poker Face). The series also features Abbi Jacobson (Broad City), Andrew Dismukes (Saturday Night Live), Bowen Yang (Saturday Night Live, Fire Island), Gary Anthony Williams (Night Court), Lennon Parham (Minx), Jay Ellis (Top Gun: Maverick), Kemah Bob (Springleaf), and John Waters (Hairspray).
Tackling anxiety-eating parasites and illegal time loops in deep space, the off-the-cuff comedy features many A-list Hollywood stars lending their voices, offering loads of charm in the wacky sci-fi series. With colorful characters and feisty personalities, expect more mayhem, extraterrestrial viruses, and unique creatures in the zany comedy.
All 8 episodes of The Second Best Hospital in the Galaxy are available to stream exclusively on Prime Video.
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